
指南指出,不同国家拥有的诊断能力,测序设备,以及对基因组数据的分析能力都不相同,因此应该根据自身的能力范围,设定切合实际的目标。通过基因组测序,可以达到的公共健康目标包括:发现和进一步表征新冠病毒并且协助开发应对手段;监控新冠病毒的传播和地域分布;监控新冠病毒的演变并协助开发应对手段。
限制传播仍然是防止新冠病毒进一步演变的重要手段
不同新冠病毒突变体都携带相似的基因变异显示,在世界各地不同的新冠病毒在演化方向上有一定的一致性。而病毒的基因突变是在不断传播和增殖的过程中产生的,因此只要病毒不断传播和增殖,即使没有输入病例,造成新冠病毒传播力提高或者逃避中和抗体识别的基因变异仍然有可能产生。除了通过基因组测序监控病毒演变之外,接种新冠疫苗,提高对新冠病毒的免疫力,以及保持社交距离和良好个人卫生习惯,都能够帮助控制病毒的传播,从而降低它们进一步产生突变的机会。
参考资料:
[1] Alarming COVID variants show vital role of genomic surveillance. Retrieved January 15, 2021, from https://www.nature.com/articles/d41586-021-00065-4
[2] Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2. Retrieved January 15, 2021, from https://virological.org/t/tracking-the-international-spread-of-sars-cov-2-lineages-b-1-1-7-and-b-1-351-501y-v2/592
[3] New variant report. Retrieved January 15, 2021, from https://cov-lineages.org/global_report.html
[4] Dr Deepti Gurdasani. Retrieved January 15, 2021, from https://www.qmul.ac.uk/whri/people/academic-staff/items/gurdasanideepti.html
[5] How Dangerous Are New COVID-19 Strains? Retrieved January 15, 2021, from https://www.cfr.org/in-brief/how-dangerous-are-new-covid-19-strains
[6] Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings. Retrieved January 15, 2021, from https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586
[7] Estimates of severity and transmissibility of novel South Africa SARS-CoV-2 variant 501Y.V2. Retrieved January 15, 2021, from https://cmmid.github.io/topics/covid19/reports/sa-novel-variant/2021_01_11_Transmissibility_and_severity_of_501Y_V2_in_SA.pdf
[8] SARS-CoV-2 genomic sequencing for public health goals: Interim guidance, 8 January 2021. Retrieved. Retrieved January 15, 2021, from https://www.who.int/publications/i/item/WHO-2019-nCoV-genomic_sequencing-2021.1
[9] Statement on the sixth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic. Retrieved January 15, 2021, from https://www.who.int/news/item/15-01-2021-statement-on-the-sixth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic
[10] Greaney et al., (2021). Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition. Cell Host & Microbe, https://doi.org/10.1016/j.chom.2020.11.007
[11] Genomic sequencing of SARS-CoV-2. Retrieved January 15, 2021, from https://apps.who.int/iris/bitstream/handle/10665/338480/9789240018440-eng.pdf?sequence=1&isAllowed=y
[12] SARS-CoV-2 genomic sequencing for public health Goals. Retrieved January 15, 2021, from https://apps.who.int/iris/bitstream/handle/10665/338483/WHO-2019-nCoV-genomic_sequencing-2021.1-eng.pdf?sequence=1&isAllowed=y
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